Atomic manipulation is the extreme limit of nanotechnology. I will discuss the manipulation of polyatomic molecules – notably chlorobenzene (C6H5Cl or PhCl) – anchored to a silicon surface, with a focus on new mechanisms  for single molecular manipulation via electron injection. Such mechanisms may (eventually) be relevant to chip-scale molecular manufacturing. I will report site-specific non-local atomic manipulation (leading to molecular desorption) of PhCl : effectively this is 'remote control' of molecular manipulation. This non-local electron attachment mechanism is also thermally activated (barrier 0.4 eV) and suppressed by the proximity of the STM tip itself, both results explicable in terms of electron-driven excitation to an intermediate physisorbed state. Moreover we find that C-Cl bond dissociation in the molecule is also thermally activated , with an energy barrier of 0.8 ± 0.2 eV, which we correlate thermal excitation to the physisorbed (precursor) state of the molecule, where electron attachment occurs.
The controlled deposition of size-selected nanoclusters, assembled from atoms in the gas phase, is a novel route to the fabrication of surface features of size <10 nm . Monodispersed, monometallic and bimetallic  cluster arrays represent new model catalysts  and a route to protein biochips . Theoretical treatments of the atomic structure of clusters far outstrip direct experimental measurements. Here the atomic structure of the deposited clusters is revealed experimentally  by aberration-corrected scanning transmission electron microscopy (STEM) in the high-angle annular dark field (HAADF) regime; we can "count" atoms  and thus obtain 3D information rather than just 2D projections. Results include mass spectrometry of passivated Au clusters , atomic imaging of Au adatom dynamics on the surface of Au923 magic-number nanoclusters , first atomic imaging of small Au clusters, notably Au55 and Au20 [12,13] and a method to explore the potential energy landscape of clusters, by the purposeful transformation of clusters under the e-beam to more stable configurations . We hope these new data will help to enhance theoretical treatments of both cluster structure and dynamics, e.g., via refinement of empirical potentials.
Finally, a new kind of cluster beam source, designed to allow super-abundant generation of size-selected nanoclusters including binary systems, will be proposed.
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